2020

Relja B, Huber-Lang M, van Griensven M, Hildebrand F, Maegele M, Nienaber U, Brucker DP, Sturm R, Marzi I. A nationwide fluidics biobank of polytraumatized patients: implemented by the Network "Trauma Research" (NTF) as an expansion to the TraumaRegister DGU ® of the German Trauma Society (DGU). Eur J Trauma Emerg Surg. 2020; 46(3): 499-504. doi: 10.1007/s00068-019-01193-3. 

2022

Lupu L, Horst K, Greven J, Mert Ü, Ludviksen JAK, Pettersen K, Lau C, Li Y, Palmer A, Qin K, Zhang X, Mayer B, van Griensven M, Huber-Lang M, Hildebrand F, Mollnes TE. Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma. Front Immunol. 2022 Aug 18;13:952267. doi: 10.3389/fimmu.2022.952267.

Weber, B.; Franz, N.; Marzi, I.; Henrich, D.; Leppik, L. Extracellular vesicles as mediators and markers of acute organ injury: current concepts. Eur J Trauma Emerg Surg 2022, 1–20, doi:10.1007/s00068-021-01607-1.

2023

Fachet M, Mushunuri RV, Bergmann CB, Marzi I, Hoeschen C, Relja B. Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma. Front Immunol. 2023 Dec 12;14:1281674. doi: 10.3389/fimmu.2023.1281674. eCollection 2023. PMID: 38193076

Groven RVM, Greven J, Mert Ü, Horst K, Zhao Q, Blokhuis TJ, Huber-Lang M, Hildebrand F, van Griensven M. Circulating miRNA expression in extracellular vesicles is associated with specific injuries after multiple trauma and surgical invasiveness. Front Immunol. 2023; 14: 1273612. doi: 10.3389/fimmu.2023.1273612

Haussner F, Maitz A, Rasche V, Hoffmann A, Braumüller S, Lupu L, Ignatius A, Neff TA, Palmer A, Huber-Lang M. Intestinal damage and immune response after experimental blunt abdominal trauma. Shock. 2023 Dec 1;60(6):784. doi: 10.1097/SHK.0000000000002302. PMID: 38153806 

Weber, B.; Henrich, D.; Hildebrand, F.; Marzi, I.; Leppik, L. THE ROLES OF EXTRACELLULAR VESICLES IN SEPSIS AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME. Shock 2023, 59, 161–172, doi:10.1097/SHK.0000000000002010.

Weber, B.; Henrich, D.; Schindler, C.R.; Marzi, I.; Leppik, L. Release of exosomes in polytraumatized patients: The injury pattern is reflected by the surface epitopes. Front. Immunol. 2023, 14, 1174, doi:10.3389/fimmu.2023.1107150.

Weber, B.; Sturm, R.; Henrich, D.; Lupu, L.; Rottluff, K.; Marzi, I.; Leppik, L. Diagnostic and Prognostic Potential of Exosomal Cytokines IL-6 and IL-10 in Polytrauma Patients. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241411830.

Weber, B.; Sturm, R.; Henrich, D.; Marzi, I.; Leppik, L. CD44+ and CD31+ extracellular vesicles (EVs) are significantly reduced in polytraumatized patients with hemorrhagic shock - evaluation of their diagnostic and prognostic potential. Front. Immunol. 2023, 14, 1196241, doi:10.3389/fimmu.2023.1196241.

2024

Barth H, Worek F, Steinritz D, Papatheodorou P, Huber-Lang M. Trauma-toxicology: concepts, causes, complications. Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2935-2948. doi: 10.1007/s00210-023-02845-3

Becker N, Franz N, Eguchi A, Wagner A, Sturm R, Rinderknecht H, Kobayashi Y, Iwasa M, Weber B, Marzi I, Relja B. Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma. Front Immunol. 2024 Jun 12;15:1390380. doi: 10.3389/fimmu.2024.1390380. eCollection 2024. PMID: 38933277

Feth M, Hezel F, Gröger M, Hogg M, Zink F, Kress S, Hoffmann A, Calzia E, Wachter U, Radermacher P, Merz T. Metabolic Effects of Sodium Thiosulfate During Resuscitation from Trauma and Hemorrhage in Cigarette-Smoke-Exposed Cystathionine-γ-Lyase Knockout Mice. Biomedicines. 2024 Nov 12;12(11):2581. doi: 10.3390/biomedicines12112581.

Hörauf, JA et al. Extracellular Vesicles (EV) epitopes as potential biomarker candidates in patients with traumatic spinal cord injury, Front. Immunol. Volume 15 – 2024. doi: 10.3389/fimmu.2024.1478786

Li Y, Horst K, Greven J, Mert Ü, Lupu L, Palmer A, Doerfer L, Zhao Q, Zhang X, Halbgebauer R, Ignatius A, Marzi I, van Griensven M, Balmayor E, Hildebrand F, Mollnes TE, Huber-Lang M. Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model. Front Immunol. 2024 Nov 21;15:1434274. doi: 10.3389/fimmu.2024.1434274.

Ritter, A.; Han, J.; Bianconi, S.; Henrich, D.; Marzi, I.; Leppik, L.; Weber, B. The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury. Int. J. Mol. Sci. 2024, 25, doi:10.3390/ijms252011282.

Ritter, A.; Lötterle, L.; Han, J.; Kalbitz, M.; Henrich, D.; Marzi, I.; Leppik, L.; Weber, B. Evaluation of New Cardiac Damage Biomarkers in Polytrauma: GDF-15, HFABP and uPAR for Predicting Patient Outcomes. Journal of clinical medicine 2024, 13, doi:10.3390/jcm13040961.

Schindler CR, Hörauf JA, Weber B, Schaible I, Marzi I, Henrich D, Leppik L. Identification of novel blood-based extracellular vesicles biomarker candidates with potential specificity for traumatic brain injury in polytrauma patients. Front Immunol. 2024 Mar 12;15:1347767. doi: 10.3389/fimmu.2024.1347767. PMID: 38533491; PMCID: PMC10963595.

Weber, B.; Henrich, D.; Marzi, I.; Leppik, L. Decrease of exosomal miR-21-5p and the increase of CD62p+ exosomes are associated with the development of sepsis in polytraumatized patients. Molecular and cellular probes 2024, 74, 101954, doi:10.1016/j.mcp.2024.101954.

Weber, B.; Ritter, A.; Han, J.; Schaible, I.; Sturm, R.; Relja, B.; Huber-Lang, M.; Hildebrand, F.; Pallas, C.; Widera, M.; et al. Development of a Sampling and Storage Protocol of Extracellular Vesicles (EVs)-Establishment of the First EV Biobank for Polytraumatized Patients. Int. J. Mol. Sci. 2024, 25, doi:10.3390/ijms25115645.

2025

Feth M, Gracco M, Gröger M, Hogg M, Kress S, Hoffmann A, Calzia E, Wachter U, Radermacher P, Merz T. Sodium thiosulfate for resuscitation after murine trauma-and-hemorrhage. Intensive Care Medicine Experimental under review

Groven RVM, Mert Ü, Greven J, Horst K, Joris V, Bini L, Poeze M, Blokhuis TJ, Huber-Lang M, Hildebrand F, van Griensven M. Early total care and damage control orthopaedics result in partially contrasting patterns of microRNA expression at the fracture site and in the systemic circulation : an animal study. Bone Joint J. 2025; 107 (2): 193-203. doi: 10.1302/0301-620X.107B2.BJJ-2024-0160.R3.

Han, J.; Leppik, L.; Sztulman, L.; Rosa, R. de; Pfeiffer, V.; Busse, L.-C.; Kontaxi, E.; Adam, E.; Henrich, D.; Marzi, I.; et al. Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiomyocyte Damage. Cells 2025, 14, 300, doi:10.3390/cells14040300.

Hörauf JA, Singh A, Voth M, Moheimani H, Schindler CR, Relja B, Leppik L, Marzi I, Henrich D. Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker. Diagnostics (Basel). 2025 Jan 14;15(2):179. doi: 10.3390/diagnostics15020179. PMID: 39857063

Sturm R, Haag F, Bergmann CB, Marzi I, Relja B. Alcohol drinking leads to sex-dependent differentiation of T cells. Eur J Trauma Emerg Surg. 2025 Jan 27;51(1):87. doi: 10.1007/s00068-024-02732-3. PMID: 39870931